Ruby is a village on the left bank of the Yukon River south of the junction of Melozitna River.
Gold was discovered on Ruby Creek, near the site of this village in 1907. However a town did not develop until 1911 when gold was discovered in Long Creek and a "stampeed" followed. A substantial town grew in one year and for the next several years the population was more than 1,000. The Ruby post office was established in 1912. By 1920 the population was reduced to 128 and has remained at less than 200 since.
Marcus Baker, of the U.S. Geological Survey, recorded in his 1906 Geographic Dictionary of Alaska: "Lozi-koket: Indian village, on left bank of the Yukon, oppisite the mouth of Melozi (Melozitna) river... Name taken from Edwatds' Track Chart of the Yukon, 1899"